Switch medication from vortioxetine to doxepine.[2]
[3]
Stop vortioxetine
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start doxepine
- Day 9: start administration of doxepin in a normal dosage of 25 mg/day.
- Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[4]
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ European Medicines Agency | SmPC Brintellix 5 mg.
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Stop vortioxetine 
Start doxepine
More information