Switch medication from nortriptyline to clomipramine.[1]
[2]
Stop nortriptyline
- Day 1: Decrease with about 25% of the original dose per 3 days.
Start clomipramine
- No wash-out period is needed.
- Day 1: Increase with about 25% of target dose per 3 days.
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- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop nortriptyline 
Start clomipramine
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