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Switch medication from vortioxetine to moclobemide.[1] [2]
Stop vortioxetine - Decrease with about 25% of original dose every 3 days
- stop and wait 14 days for washout
Start moclobemide- a wash-out period of 2 weeks is necessary. [3] [4]
- Start at the first day after the washout period with about 25% of target dose.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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