Switch medication from moclobemide to doxepin.[2]
[3]
Stop moclobemide
- Decrease with about 25% of original dose every 3 days
- Stop and wait for about 24 hour as a washout period
Start doxepin
- Start with the initial dose
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- Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[4]
- “Start low, go slow” is not required, but caution is necessary.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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Stop moclobemide 
Start doxepin
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