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Switch medication from sertraline to tranylcypromine.[1] [2]
Stop sertraline - Decrease with about 25% of original dose every 3 days
- Stop and wait 7 days for washout
Start tranylcypromine- Start tranylcypromine in a low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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