Switch medication from trazodone to tranylcypromine.[1]
[2]
Stop trazodone
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Start tranylcypromine
- a wash-out period of 3 days is necessary.
- after the washout period, start administration of tranylcypromine in a dosage of 20 mg/day.
- If necessary, increase dosage of tranylcypromine.
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- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop trazodone 
Start tranylcypromine
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