Switch medication from sertraline to tranylcypromine.[1]
[2]
Stop sertraline
- Before day 0: gradually reduce dosage of sertraline to a maximum of 25 mg/day, when this dosage is > 25 mg/day.
- Day 1: stop administration of sertraline.
Start tranylcypromine
- Day 1-7: a wash-out period of one week is necessary.
- Day 8: start tranylcypromine the next day in a low dosage of 20 mg/day for one week.
- Day 15: after this week the dosage of tranylcypromine can be increased if necessary.
More information
- A switch from sertraline to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case.
- Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop sertraline 
Start tranylcypromine
More information