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Partial agonist-Partial agonist

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Partial agonists

Aripiprazole
Brexpiprazole
Cariprazine

Partial agonists

Aripiprazole
Brexpiprazole
Cariprazine

Switch medication from Partial agonist to Partial agonist.[1] [2]
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.

Nietinrijdenbord.png Stop Partial agonist
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Partial agonist
  • Day 1-3: start 50% of target dose
  • Day 4-7: target dose
Infobord.png More information
PartialtoPartial.jpg
Nietinrijdenbord.png — Partial agonist
Eenrichtingbord.png — Partial agonist


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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