Switch medication from trazodone to duloxetine.[1]
[2]
Stop trazodone
- Day 1: Decrease dose to 50%
- Day 8: Stop
Start duloxetine
- Day 1: Start with 50% of the target dose
- Day 8: Increase dose to 100% of the target dose
- Day 9 and after: Gradually increase dose as necessary
More information
- Safe target dose duloxetine = 60 mg
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop trazodone 
Start duloxetine
More information