Switch medication from agomelatine to clomipramine.[1]
[2]
Stop agomelatine
- Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.[3]
Start clomipramine
- Day 2: Start administration of clomipramine in a normal dosage of 50-75 mg/day.
- Increase the dose with about 25% of the target dose every 3 days.
- Therapeutic Drug Monitoring of clomipramine is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.
More information
- A wash-out period is not necessary.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop agomelatine 
Start clomipramine
More information