Switch medication from tranylcypromine to clomipramine.[1]
[2]
Stop tranylcypromine
- Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start clomipramine
- Day 23: Start and increase the dose with about 25% of the target dose every 3 days. [3]
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- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[3]
- Tranylcypromine has to be phased out to avoid withdrawal symptoms.[4]
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ 3.0 3.1 KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
- ↑ Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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Stop tranylcypromine 
Start clomipramine
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