Switch medication from maprotiline to paroxetine.[1]
[2]
Stop maprotiline
- Day 1: reduce dosage to 50%.
- Day 8: stop
Start paroxetine
- Day 8: Start with 50% of the target dose
- Day 15: Increase dose to 100% of the target dose
- Day 16 and after: Gradually increase dose as necessary
More information
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
- Safe target dose paroxetine = 20 mg
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop maprotiline 
Start paroxetine
More information