Agomelatine-clomipramine

Agomelatine Type Antidepressant Group other links ATC-code N06AX22 EMEA valdoxan PubChem 82148 PubMed Agomelatine Kompas (Dutch) Agomelatine Wikipedia Agomelatine more info administration oral

Clomipramine Type Antidepressant Group TCA links ATC-code N06AA04 Medscape Clomipramine PubChem 2801 PubMed Clomipramine Kompas (Dutch) Clomipramine Wikipedia Clomipramine more info T1/2 36h administration O

Switch medication from agomelatine to clomipramine.

Stop agomelatine

• Day 1: Stop agomelatine.
• Agomelatine can be stopped abruptly for every dosage.

Start clomipramine

• Day 2: Start administration of clomipramine in a normal dosage of 50-75 mg/day.
• Increase the dose with about 25% of the target dose every 3 days.
• Therapeutic Drug Monitoring of clomipramine is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.

More information

• A wash-out period is not necessary.
  

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