Switch medication from citalopram to bupropion.[1]
[2]
Stop citalopram
- Day 1: reduce dosage of citalopram to a maximum of 20 mg/day
- Day 8: reduce dosage of citalopram to 10 mg/day
- Day 15: stop citalopram
Start bupropion
- Day 16: start bupropion in a normal dosage of 150 mg/day.
- Day 23: if necessary gradually increase the dosage of bupropion to target dose.
More information
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop citalopram 
Start bupropion
More information