Clozapine-Paliperidone LA

There are 2 switch possibities:

Number 1 (the general approach):

• Day 1: Switch to oral risperidone (or oral paliperidone): see this switch in the main cross table.
• Day 1-29: Maintain on oral risperidone (or oral paliperidone) and examine the effects.
• Day 30: stop oral risperidone (or oral paliperidone) and administer paliperidone-LA: see this switch in the main cross table.

Oral risperidone has better and more stable bioavailability properties than has oral 9-OH-risperidone=paliperidone. Food increases the absorption with 50-60% of the latter.

Number 2 (if a patient in the past reacted well on risperidon or paliperidone=9-OH-risperidone):

• This is not very likely in the case of being on clozapine. It is not available yet