Combining-Risperidone-Lamotrigine
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Adding lamotrigine to risperidone.
General information- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start lamotrigine- Start lamotrigine according to the general dosing advice.
Cave- A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. [7]
- Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. [6]
- ↑ 1.0 1.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
- ↑ 6.0 6.1 Drugs.com lamotrigine Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content - ↑ Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2
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Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the risperidone dosage adjusted as necessary.