Combining-Risperidone-Ziprasidone
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Adding ziprasidone to risperidone.
General information- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
Start ziprasidone- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Cave- The concurrent use of ziprasidone with other medications that can prolong the QT interval is considered contraindicated.[4]
- ↑ 1.0 1.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Interactions between risperidone and ziprasidone on drugs.com
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