Switch medication from doxepine to nortriptyline.[2]
[3]
Stop doxepine
- Day 1: Decrease with about 25% of the original dose per 3 days.
Start nortriptyline
- No wash-out period is needed.
- Day 1: Increase with about 25% of target dose per 3 days.
More information
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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Stop doxepine 
Start nortriptyline
More information