Switch medication from fluoxetine to moclobemide.[1]
[2]
Stop fluoxetine
- Decrease with about 25% of original dose every 3 days
- wait for 5-6 weeks for washout
Start moclobemide
- Start at the first day after the washout period of 5-6 weeks with about 25% of target dose.
Cave
- Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
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- The pharmacologically active metabolite norfluoxetine has a half-life of about 2 weeks.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop fluoxetine 
Start moclobemide
Cave
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