Switch medication from fluvoxamine to agomelatine.[1]
[2]
[3]
Stop fluvoxamine
- Day 1: Decrease dose to 50%
- Day 8: Stop
Start agomelatine
- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[4]
- Day 11: If necessary, increase dosage of agomelatine to 50 mg/day.
More information
- Fluvoxamine inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).[4]
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Stop fluvoxamine 
Start agomelatine
More information