Switch medication from paroxetine to venlafaxine.[1]
[2]
Stop paroxetine
- Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
- Day 8: stop administration of paroxetine.
Start venlafaxine
- No wash-out period is needed.
- Day 9: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine slows the metabolism of venlafaxine via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop paroxetine 
Start venlafaxine
More information