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Pimozide-Sertindole

Pimozide
Type Antipsychotic
Group Diphenylbutylpiperidines
links
Medscape Pimozide
PubChem 16362
PubMed Pimozide
Kompas (Dutch) Pimozide
Wikipedia Pimozide
Sertindole
Type Antipsychotic
Group Atypical AP
links
PubChem 60149
PubMed Sertindole
Kompas (Dutch) Sertindole
Wikipedia Sertindole

Switch medication from Pimozide to Sertindole.[1] [2]

Nietinrijdenbord.png Stop Pimozide
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Sertindole
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
Letopbord.png Cave
  • During this switch ECG monitoring is required because of possible QT-interval prolongation[3][4]
Infobord.png More information
Switchstandaardup en down.jpg
Nietinrijdenbord.png — Pimozide
Eenrichtingbord.png — Sertindole


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. SPC Sertindole (Dutch)
  4. SPC Sertindole
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