* '''Day 16:''' start Start administration of fluoxetine in a normal dosage of 20 mg/day.* '''Day 16:''' if necessary, increase dosage At approximately 50-25% of the original TCA dosering start fluoxetineat 100% of the target dose.
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* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize amitriptyline.