* '''Day 1:''' Stop vortioxetine.* vortioxetine can be stopped abruptly for every dosage.<ref>Multidisciplinair document Afbouwen Overige Antidepressiva 2023</ref>{{stopVortioxetine14dwashout}}

* '''Day 8-21:''' a wash-out period of two weeks is necessary.<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetineStarttranyl}}</ref>* '''Day 22:''' Start administration of tranylcypromine in low dosage of 20 mg/day for one week.* '''Day 29:''' after this week the dosage of tranylcypromine can be increased if necessary.