* '''Day 1-212:''' A wash-out period is neededstart administration of vortioxetine in a low dosage of 5 mg/day. * '''Day 229:''' Start vortioxetine in a increase dosage of vortioxetine to 10 mg/day.* '''After day 28 Day 29:''' If necessary, gradually increase gradually the dosage of vortioxetineif necessary.| info = * Fluoxetine slows and norfluoxetine slow the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.* {{theorSS}}{{reviewlongt1/2fluvox}}