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Fluoxetine-maprotiline

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~~Caution is necessary for at least four weeks.~~* '''Day 25:''' start administration of maprotiline in a low dosage of 25 mg/day.

* '''Day 15:''' increase dosage of maprotiline to 50 mg/day.

* '''Day 2920 and after:''' gradually increase dosage of maprotiline ~~to 75 mg/day and more~~if necessary.

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* Fluoxetine and norfluoxetine slow the metabolism of maprotiline via CYP2D6.

* Start low, go slow for maprotiline.}}

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