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* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 8:''' start administration of sertraline in a normal dosage of 50 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.}}