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Amitriptyline-hypericum

404 bytes added, 15:58, 28 October 2015
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* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day, when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.* '''Day 8:''' stop administration of amitriptyline.{{stopAmitriptyline1}}
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* '''Day 815-1422:''' a wash-out period of one week is necessary.<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref> * '''Day 1523:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.| caveat = {{caveSS}}| info ={{HypericumInfo}} * Hypericum slows the metabolism of amitriptyline via CYP3A4.}}
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