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Created page with '{{ Drugswitch | from = hypericum | to = amitriptyline | stop = * Administration of hypericum can be stopped abruptly. | start = * '''Day 1-7:''' a wash-out period of one we...'
{{ Drugswitch
| from = hypericum
| to = amitriptyline
| stop =
* Administration of hypericum can be stopped abruptly.
| start =
* '''Day 1-7:''' a wash-out period of one week is necessary.
* * '''Day 8:''' start administration of amitriptyline in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine to 50 mg/day.
* Start low, go slow.
| info =
* Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum.}}
| from = hypericum
| to = amitriptyline
| stop =
* Administration of hypericum can be stopped abruptly.
| start =
* '''Day 1-7:''' a wash-out period of one week is necessary.
* * '''Day 8:''' start administration of amitriptyline in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine to 50 mg/day.
* Start low, go slow.
| info =
* Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum.}}