838
edits
Changes
Created page with '{{ Drugswitch | from = hypericum | to = clomipramine | stop = * Administration of hypericum can be stopped abruptly. | start = * '''Day 1-7:''' a wash-out period of one week...'
{{ Drugswitch
| from = hypericum
| to = clomipramine
| stop =
* Administration of hypericum can be stopped abruptly.
| start =
* '''Day 1-7:''' a wash-out period of one week is necessary.
* '''Day 8:''' start administration of clomipramine in a dosage of 50 mg/day.
* If necessary, increase dosage of clomipramine to 75 mg/day.
* Start low, go slow.
| info =
* Hypericum slows the metabolism of clomipramine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}
| from = hypericum
| to = clomipramine
| stop =
* Administration of hypericum can be stopped abruptly.
| start =
* '''Day 1-7:''' a wash-out period of one week is necessary.
* '''Day 8:''' start administration of clomipramine in a dosage of 50 mg/day.
* If necessary, increase dosage of clomipramine to 75 mg/day.
* Start low, go slow.
| info =
* Hypericum slows the metabolism of clomipramine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}