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* '''Day 1-7:''' a wash-out period of one week is necessary.
* '''Day 8:''' start administration of amitriptyline in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine amitriptyline to 50 mg/day.
* Start low, go slow.
| info =
* Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericumhypericumm, so caution is necessary.}}