* Gradually '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/ day. * When a '''Day 1:''' reduce the dosage of 300 moclobemide to 150 mg/day is reached, .* '''Day 8:''' stop administrationof moclobemide.

* '''Day 18-29:''' a wash-out period of two days is necessary. * '''Day 310:''' start mianserine after this period in a low dosage of 30 mg/day.}}