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* '''Day 15:''' stop administration of tranylcypromine.
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* '''Day 115-28:''' simultaneously start administration of agomelatine in a dosage wash-out period of 25 mg/dayone week is necessary.* '''Day 1529:''' only continue start administration of agomelatinein a dosage of 25 mg/day. * If necessary, increase dosage of agomelatine to 50 mg/day.
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* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
* Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
* Occurrence of the serotonin syndrome is theoretically possible.}}