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A wash-out period of two weeks is necessary.
* '''Day 1-14:''' wash-out period
* '''Day 14-21:''' start tranylcypromine at half the usual dosage for one week, 20 mg/day. * '''Day 22:''' increase dosage of tranylcypromineif necessarytranylcypromine.
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* By considering a wash-out period of two week (>5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. }}