| stop =

* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.

* '''Day 8:''' stop administration of trazodone.

| start =

* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.

* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}