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* '''Before day 0:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of nortriptylineto 25 mg/day.
* '''Day 8:''' reduce dosage of nortriptyline to 10 mg/day.* '''Day 15:''' stop administration of nortriptyline.
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 158:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}