* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-730:''' a wash-out period of one week at least two weeks is necessary.* '''Day 831:''' start administration of bupropion in a dosage of 150 mg/day.* If necessary, increase dosage of bupropion to 300 mg/day.

* Occurrence A wash-out period is necessary.* Hypericum induces enzymes of the serotonin syndrome is theoretically possible, so caution is necessaryCYP P-450 type and P-gp.* Hypericum probably has MAO-inhibiting properties.}}