* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-730:''' a wash-out period of one week at least two weeks is necessary.* '''Day 831:''' start administration of dosulepine in a dosage of 50 doslulepine 25 mg/day.| info = * If necessary, increase dosage Occurrence of dosulepine to 75 mg/daythe serotonin syndrome is possible without wash-out period.* Start low, go slowHypericum induces enzymes of the CYP P-450 type and P-gp.* Hypericum probably has MAO-inhibiting properties.}}