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| start =
* '''Day 15-30:''' a wash-out period of at least two weeks is necessary.
* '''Day 31:''' start doxepin 50 25 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without wash-out period.
* Hypericum induces enzymes of the CYP P-450 type and P-gp.
* Hypericum probably has MAO-inhibiting properties.}}