* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-730:''' a wash-out period of one week at least two weeks is necessary.* '''Day 831:''' start administration of paroxetine in a dosage of 20 mg/day.* If necessary, increase dosage of paroxetine.

* Occurrence of the serotonin syndrome is theoretically possible, so caution is necessarywithout wash-out period.* Hypericum induces enzymes of the CYP P-450 type and P-gp.* Hypericum probably has MAO-inhibiting properties.}}