| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/day, when this dosage is > 75 mg/day. * '''Day 1:''' reduce dosage of venlafaxine to 37,5 mg/day.* '''Day 8:''' stop administration of venlafaxine.{{downVenla}}
| start =
* '''Day 814-1421:''' a wash-out period of one week is necessary.* '''Day 1522:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Hypericum slows the metabolism of venlafaxine via CYP3A4. }}