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Bupropion-trazodone

45 bytes removed, 16:06, 20 July 2009

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* When a dosage of 150 mg/day is reached, stop administration.

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* A wash-out period of one week is recommended. * Start trazodone the ~~next~~ same day in a normal dosage of 100-150 mg/day.

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* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.

* Bupropion possibly slows the metabolism of trazodone by CYP2D6.

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