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* '''Day 1-28:''' administration of bupropion in a low dosage of 150 mg/day.
* '''Day 29 en on:''' if necessary increase bupropion to 300 mg/day.
| info =
* Fluoxetine and bupropion inhibit both their metabolism through CYP P450-enzymes.
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
}}