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* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
| start =
* '''Day 14:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
* '''Day 8:''' stop administration of imipramine and continue administration of duloxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.}}