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* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
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* '''Day 14:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.
* '''Day 8:''' stop administration of imipramine and continue administration of sertraline in a dosage of 50-100 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Sertraline is a weak inhibitor of CYP2D6, which metabolizes imipramine. }}