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* '''Before day 0:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
* '''Day 37:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 14:''' stop dosage of maprotiline.
| start =
* '''Day 17:''' simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.* '''Day 814:''' stop administration of maprotiline and continue administration of mirtazapine.}}