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| to = agomelatine
| stop =
* '''Before day 0:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day, when this dosage is > 75 mg/day.
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
* '''Day 87:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 1514:''' stop administration dosage of maprotiline.
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 1514:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}