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Caution is necessary for at least four weeks.
* '''Day 1:''' start administration of clomipramine in a low dosage of 25 mg/day.
* '''Day 8:''' increase dosage of clomipramine to 50-75 mg/day.* '''Day 1528:''' gradually increase dosage of clomipramine to 75-150 mg/dayand more.
| info =
* Fluoxetine slows the metabolism of clomipramine via CYP2D6.
* Desmethylfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.* Start low, go slow for clomipramine.}}