| stop = * Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{{stopfluox}}

Caution is necessary for at least four weeks.* '''Day 15:''' start administration of clomipramine in a low dosage of 25 37.5 mg/day.* '''Day 815:''' increase dosage of clomipramine to 50 75 mg/day.* '''Day 2820 and after:''' gradually increase dosage of clomipramine to 75 mg/day and moreif necessary.

* {{TCAplasmalevelmonitoring}}* Fluoxetine slows and norfluoxetine slow the metabolism of clomipramine via CYP2D6. * Desmethylfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.{{longt1/2fluvox}}