* Gradually '''Before day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day. * When '''Day 1:''' reduce a dosage of 60 mg/day is reached, to 30 mg/day.* '''Day 7:''' stop administrationduloxetine.| start = * No wash-out period is needed'''Day 10:''' start fluvoxamine 50 mg. * Start '''Day 14:''' increase administration of fluvoxamine .| info = * Fluvoxamine inhibits the next day in a normal dosage metabolism of 50 mg/dayduloxetine through CYP1A2.* {{theorSS}}}}